Decreased production of glucose from the liver

This is correct! Metformin activates AMPK-dependent protein kinase (AMPK) due to a reduction in cellular energy stores. AMPK reduces hepatic glucose production (gluconeogenesis) through inhibition of expression of genes that are important in gluconeogenesis. Remember that gluconeogenesis contributes to hyperglycaemia in diabetes.


Further Developments

Five years later, Mr. Green reports progressive exertional dyspnoea over several months, now short of breath after one flight of stairs, with new orthopnoea requiring two pillows and intermittent paroxysmal nocturnal dyspnoea. The medical notes show lack of follow-up over the past 18 months, which Mr. Green explains were due to a job change. He reports that his home blood pressure readings have been on the high side.

On examination his blood pressure is 132/78 mm/Hg and his BMI is now 30 kg/m2; physical examination shows bibasilar rales. Mr. Green is scheduled for an echocardiogram and invasive coronary angiography with a contrast agent to assess for obstructive coronary artery disease.

What is the most appropriate advice for Mr. Green for use of metformin during this time?  

  • Starts smoking again [undo]
  • How do scientists measure brain changes? [undo]
  • Interphase, prophase, metaphase, anaphase, telophase [undo]
  • Opción 3 [undo]
  • Ξεκινήστε βυθίζοντας την πιπέτα μέσα στο υγρό που σκοπεύετε να αναρροφήσετε [undo]
  • Εκπαιδεύοντας τον ασθενή σας στην αυτοδιαχείριση [undo]
  • Option 2 [undo]
  • Відмовитися від ліків, оскільки я вже почуваюся краще. [undo]
  • EMB [undo]
  • Activates vasopressin receptors [undo]
  • Option 2: Only B is correct [undo]
  • Τον παρακολουθείτε για λίγες ώρες [undo]
  • Starts seeing a therapist [undo]
  • Pine tree cones [undo]
  • Trăsături [undo]
  • Permanently stop taking metformin [undo]
  • Carbimazole [undo]
  • LB [undo]
  • Mudarse a una casa nueva. [undo]
  • Definiția 2 [undo]
  • White blood cells [undo]
  • MSA [undo]
  • Observing the wrong section of the tip [undo]
  • EMB [undo]
  • Ο Κώστας έχει αναλάβει το ρόλο του πατέρα. [undo]
  • Domain 3: The "Warning Signs" [undo]
  • Start a therapy [undo]
  • Laboratory Scales I [undo]
  • To protect our clothes underneath. White is a universal colour which you can find in any country [undo]
  • Option 2 [undo]
  • Πέψη DNA με Περιοριστικές Ενδονουκλεάσες: Επιλογή του Κατάλληλου Ενζύμου [undo]
  • Semaglutide [undo]
  • Probele B și D sunt contaminate și au o încărcare bacteriană ridicată [undo]
  • Increases her coffee intake [undo]
  • Probele B, C și D sunt contaminate și au o încărcare bacteriană ridicată [undo]
  • Διπλοειδές και Απλοειδές [undo]
  • Genotip [undo]
  • Dominant and recessive [undo]
  • Απάντηση 3 [undo]
  • Genotype [undo]
  • Pentru a ne proteja hainele de dedesubt. Albul se potrivește cu orice nuanță de culoare a pielii [undo]
  • Decision: Initial Approach [undo]
  • Decreased production of glucose from the liver [undo]

Map: Michael Green_GEMD_2 (1116)
Node: 21117
Score:

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