PPIs are weak bases converted by CYP450 enzymes to the active form in parietal cells

Hmmm... This is not quite right now, is it? PPIs are indeed weak bases but they are not activated by CYP450 enzymes in the stomach. Remember that CYP450 enzymes are primarily involved in drug metabolism in the liver and in the small intestine.

Please go back and re-consider. 

 



  • Mechanism of action of PPIs

Map: Connor Mason_UNIC (1100)
Node: 20907
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  • PPIs are weak bases activated by protonation in parietal cells
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  • PPIs are weak acids converted by CYP450 enzymes to the active form in parietal cells
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  • PPIs are weak bases converted by CYP450 enzymes to the active form in parietal cells

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