Mechanism of action of PPIs

Mechanism of action of PPIs

In considering the mechanism of action of PPIs, which statement best explains their therapeutic effect in Mr. Mason?

PPIs are weak bases activated by protonation in parietal cells
PPIs are weak bases converted by CYP450 enzymes to the active form in parietal cells
PPIs are weak bases that become activated by colonic bacteria
PPIs are weak acids activated by protonation in parietal cells
PPIs are weak acids converted by CYP450 enzymes to the active form in parietal cells

Map: Connor Mason_UNIC (1100)
Node: 20904
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Mechanism of action of PPIs

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