Vitamin K

Considering that Kylie is in no immediate risk, your supervisor agrees that vitamin K, should be administered to counteract the effects of warfarin, a vitamin K antagonist. 

You explain that erythromycin (macrolide antibiotic) decreased the metabolism and clearance of warfarin, which led to toxic build-up of warfarin in her blood. This, combined with aspirin, increased her risk of bleeding. 

You advise Kylie to switch to dabigatran (direct oral anticoagulant), to avoid such risks in the future. Kylie agrees that it will be easier to manage dabigatran, given these events. 

What is the mechanism of action of dabigatran?