All answers

•Starts plasma exchange (x3) and steroids
•LDH decrease, but platelets and creatinine remain abnormal
•Shiga toxin: negative
•No evident underlying causes – normal B12
•ADAMTS13: 45%
What do we do next?


  • Start complement inhibition (eculizumab/ravulizumab)
  • Start caplacizumab and rituximab, without plasma exchange

Map: TMA (792)
Node: 16362
Score:

reset

OpenLabyrinth
OpenLabyrinth is an open source educational pathway system

Review your pathway

  • Bone Marrow Aspirate
  • Start caplacizumab and rituximab, without plasma exchange
  • Thrombotic thrombocytopenic purpura (TTP)
  • ADAMTS13 activity
  • All answers

Reminder

FINISH

Time is up