Glyceryl trinitrate (organic nitrate)

Well-done! Sildenafil is a phosphodiesterase inhibitor which potentiates the nitric oxide pathway. GTN being a nitric oxide donor, can interact with sildenafil via potentiation of the same pathway. Activation of the nitric oxide pathway leads to venodilation (reduced preload) and to a lesser extend vasodilation, resulting in low blood pressure.  

  • Epilogue

Map: Mattias Garcia_ORU (1096)
Node: 20741
Score:

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OpenLabyrinth
OpenLabyrinth is an open source educational pathway system

Review your pathway

  • Isosorbite mononitrate
  • Simvastatin (Statin)
  • Inhibits ADP binding to its receptor on platelets
  • Amlodipine
  • Glyceryl trinitrate (organic nitrate)

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