Focus on karyotypes.

You: ‘We used karyotypes for Down’s Syndrome. Surely, it’s the same for CF?”

Dr. Antoniou: ‘We already discussed this previously but as a reminder small mutation in the CFTR gene aren’t typically visible on a karyotype. Karyotyping reveals large-scale chromosome changes, not single-gene mutations.’

Try Again: 

What is the next step in this analysis?