Glyceryl trinitrate (organic nitrate)Well-done! Sildenafil is a phosphodiesterase inhibitor which potentiates the nitric oxide pathway. GTN being a nitric oxide donor, can interact with sildenafil via potentiation of the same pathway. Activation of the nitric oxide pathway leads to venodilation (reduced preload) and to a lesser extend vasodilation, resulting in low blood pressure. |
Map: Mattias Garcia_ORU (1096)
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Review your pathway |