Increased LDL uptake in hepatocytes

Increased LDL uptake in hepatocytes

Well-done! Statins decrease the synthesis of cholesterol in the liver through inhibition of the rate-limiting enzyme, HMG-CoA reductase. Therefore, LDL is removed from the plasma and returned to the liver to restore hepatocyte cholesterol levels.

Further developments

Map: Mattias Garcia_ORU (1096)
Node: 20729
Score:

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Glyceryl trinitrate (organic nitrate)
Digoxin (digitalis, positive inotropic drug)
Increased elimination of cholesterol
Sacubitril-valsartan (ARNI)
Ramipril (ACE inhibitor)
Emergency Department
Presentation
Glyceryl trinitrate (organic nitrate)
Decreased levels of HDL
Emergency Department
Decreased absorption of dietary cholesterol
Decreased absorption of dietary cholesterol
Increased LDL uptake in hepatocytes
Warfarin may be commenced as an alternative to apixaban
Increased elimination of cholesterol
Decreased levels of HDL
Warfarin may be commenced but LMWH is also needed initially
Presentation
Presentation
Increased LDL uptake in hepatocytes

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